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Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis,〔Madan V, Griffiths CE. "Systemic ciclosporin and tacrolimus in dermatology. ''Dermatol Ther.'' 2007 Jul-Aug;20(4):239-50. 〕 rheumatoid arthritis,〔Kitahara K, Kawai S. "Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. ''Curr Opin Rheumatol.'' 2007 May;19(3):238-45. Review. 〕 dry eye and other auto-immune related conditions. A variety of pre-clinical and clinical studies have been and are investigating its use to treat lung-related disorders via inhalation. ==Formulation== Formulation of the drug for inhalation purposes has proved challenging because of ciclosporin's poor aqueous solubility. Consequently, aerosol studies have often employed compatible solvents such as propylene glycol or ethanol〔O'Riordan TG, Iacono A, Keenan RJ, Duncan SR, Burckart GJ, Griffith BP, Smaldone GC. "Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. ''Am J Respir Crit Care Med.'' 1995 Feb;151 (2 Pt 1):516-21.〕 as the vehicle for administration by nebulizer or have used more complicated aqueous-based formulations involving liposomes or other dispersions. Dry powder inhaler as well as propellant metered dose inhaler (pMDI) formulations have also been created and evaluated in the laboratory and in early clinical studies. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Inhaled ciclosporin」の詳細全文を読む スポンサード リンク
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